Like glass, however, acrylic does tend to get dirty, especially if children like to put their fingerprints all over it, so occasionally you'll have to clean off your acrylic frames.
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Remove any picture from the frame and set it aside so it does not get wet during cleaning.
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Fill a small bowl with warm water and mix in a squirt or two of mild dishwashing liquid.
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Moisten one of the microfiber cloths with the cleaning solution.
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Wipe down the frame with the moist cloth. Be gentle, applying only a little pressure when you see stubborn fingerprints. If the outside of the frame is made of acrylic as well, wipe that down too.
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Dry off the acrylic frame with the dry microfiber cloth. Do not let it simply air dry, as evaporating water droplets may leave a soapy residue.