Use a screwdriver to remove the receptacle covers from each air conditioning vent in the household. Clean each vent cover with soap and hot water.
Extend the handle of the feather duster to reach inside the duct. Remove as much dust from the duct as possible by gently but swiftly rotating the feather duster in a clockwise direction.
Plug the vacuum cleaner into an AC outlet. Attach the crevice tool on the vacuum cleaner hose. Vacuum the remaining dust from the inside of the duct.
Spray inside each duct with an odor-eliminator spray such as Air Wick Neutra Air, Febreeze or Oust Air Sanitizer. Determine which rooms have the most nicotine odor. Use more spray to eliminate heavier odors.
Replace each receptacle cover using the screwdriver.
Install a new filter in the air conditioning system even if the filter has been in use for under 30 days.
Turn on the central air conditioning unit. The blower will circulate the cleaned air throughout the home. Continue to spray each room as needed until the smell of smoke has been removed from the home.