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Put on your face mask, safety goggles and thick work gloves. Also wear a thick layer of clothing that covers as much of your skin as possible.
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Locate the honeycomb by tracking the swarming bees. If the honeycomb is in a precarious location, such as in your garage's air vent, access it from the inside of the structure rather than the outside.
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Spray the honeycomb with pesticide from at least 10 feet away. Continue spraying until the bees begin to drop and expire. If you own or can borrow a bee smoker machine, it will help calm the bees before pesticide application.
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Allow the honeycomb to settle overnight. If you see any stray bees, eliminate them with pesticide.
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Chip away large pieces of the empty honeycomb with a trowel tool. Scrape away any stuck fragments with the edge of the tool. Place the honeycomb in a large garbage bag.
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Sweep up the dead bees and any loose honeycomb particles from the ground. Empty the dustpan into the garbage bag.
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Pour all-purpose cleaner and warm water into a plastic bucket. Saturate a scrub brush with the solution and clean away any wax and dried honey from the area. Dry with a towel.
Check out this related video from Homesteady on Youtube.