Unplug your neon sign before starting the cleaning process.
Use the hose attachment of your vacuum cleaner to remove any large dust particles and debris.
Brush away the remaining dust and debris with a soft, nylon brush. Be careful when brushing in between the tubes of your neon sign.
Apply an ammonia-based cleaning product to a soft cloth. Use the cloth to clean away any caked on substances such as nicotine. Be very careful when cleaning near the tie wires.
Fill a spray bottle with clean water and use it to rinse your neon sign.
Allow the sign to air dry completely before plugging it back in.